Preparation of Irisquinone freeze-drying Injection and its stability
- VernacularTitle:马蔺子素冻干注射剂的制备及其稳定性考察
- Author:
Xuenong ZHANG
;
Xueying YAN
;
Lihua TANG
;
Qiang ZHANG
- Publication Type:Journal Article
- Keywords:
irisquinone;
injection;
freeze-(drying);
stability
- From:
Chinese Traditional Patent Medicine
1992;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To prepare the irisquinone freeze-drying injection and investigate its stability. METHODS: The degradation pattern of irisquinone and its effects were measured. At the same time, the stability of freeze-(drying) injection by classic thermostatical test. RESULTS: Irisquinone solution was unstable to heat and its content decreased remarkably in acid and alkaline solutions. The result showed that oil/water partition coeffecient of irisquinone was very large. The irisquinone-hydropropyl1-?-cyclodextrin inclusion complex freeze-drying injection was very effective to enhance the drug stability. CONCLUSION: Irisquinone inclusion complex injection has character of good stability.
