Effect of Jingui Shenqi Pill on TNF-? expression in lungs from bleomycin A5-(induced) pulmonary fibrosis in rats
- VernacularTitle:金匮肾气丸对肺纤维化大鼠肺组织中肿瘤坏死因子?表达的影响
- Author:
Jianping SONG
;
Fangzhou LIU
;
Wei LI
;
Ruiqin LI
;
Rui ZHANG
- Publication Type:Journal Article
- Keywords:
pulmonary fibrosis;
tumor necrosis factor ?(TNF-?);
Jingui Shengi Pill;
rat
- From:
Chinese Traditional Patent Medicine
1992;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effect and mechanism of Jingui Shenqi Pill(JGSQ) on pulmonary fibrosis. METHODS: Pulmonary fibrosis was induced by bleomycinA5 in SD rats.Rats in drug group were killed after being treated by taking JGSQ daily for 28 days.The lungs of all rats were harvested for histopathological studies.The contents of tumor necrosis factor ?(TNF-?)in lungs were measured and compared. RESULTS: The degree of the alveolitis and pulmonary fibrosis, the contents of TNF-? in lungs increased significantly in the model group as compared with the normal group and the JGSQ treated group(P
