Polymorphisms of the thymidylate synthase gene promoter in primary colon cancer and its relationship with clinical pathological parameters
- VernacularTitle:胸苷酸合酶启动基因与结肠癌临床病理因素的关系
- Author:
Kaihuan YU
;
Weixing WANG
- Publication Type:Journal Article
- Keywords:
Colonic neoplasms;
Thymidylate synthase;
Single nucleotide,polymorphism
- From:
Chinese Journal of Digestion
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between polymorphisms in the thymidylate synthase promoter enhancer region(TSER) and clinical pathological characteristics of primary colon cancer.Methods TSER polymorphisms and thymidylate synthase(TS) protein were detected by PCR and immunohistochemical staining respectively in primary foci.Results There were three genotypes of TSER including homozygous with double tandem repeats(2R/2R),homozygous with triple tandem(repeats)(3R/3R) and heterozygous with both alleles(2R/3R)in 68 cases of colon cancer(6,40,22 cases respectively).The ratio of 3R/3R was significantly higher in stage of Dukes C than stages in Dukes B and Dukes A.(Dukes A16%;Dukes B30%;Dukes C 93%,?~2=28.56,P
