Expression of COX-2 in invasive ductal carcinoma of breast and its relationship with cell proliferation and angiogenesis
- VernacularTitle:乳腺浸润性导管癌组织中环氧合酶-2的表达与细胞增生和血管生成的关系
- Author:
Fenglin CAI
;
Shifu ZHOU
;
Zhaosheng MA
;
Weifeng SHI
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Cyelooxygenase 2;
Ki-67 antigen;
Mierovascular density(MVD)
- From:
Cancer Research and Clinic
2008;20(8):524-525,528
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of eyelooxygenase-2(COX-2)in invasive duetal carcinoma of breast and its relationship with cell prolireration and angiogenesis. Methotis Expression of COX-2 and Ki-67 was detected in 52 cages of breast cancer tissue by immunohistochemistry. CD34 marking vascular endothelial cell was used to measure the miemvascular density(MVD).Results The positive COX-2 expression was 57.7%in invasive duetal carcinoma of breast.The Ki-67 index was (56.07±17.37)%in COX-2 positive group while(27.32±16.28)%in the negative group,and the MVD W88 32.46±12.59 in COX-2 positive group while 25.04±10.48 in the negative group.The positive group of COX-2 protein had higher Ki-67 and MVD than that in negative group(P＜0.05).Conclusion The overexpression of COX-2 protein Were found in invasive ductal carcinoma of breast.To stimulate cell prolireration and angiogenesis may be one of the pathways of COX-2 protein to contribute to the invasion and metastasis in human breast cancer.
