Simultaneous release of index components in Gegen Qinlian Pellets
- VernacularTitle:葛根芩连微丸中指标成分的体外同步释放研究
- Author:
Qingpo LI
;
Jian YOU
;
Yongsheng WANG
;
Ying ZHAO
;
Lei YANG
;
Fude CUI
- Publication Type:Journal Article
- Keywords:
Gegen Qinlian Pellets;
extrusion-spheronization;
in vitro release
- From:
Chinese Traditional and Herbal Drugs
1994;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To obtain the same release rate of four index components with significant difference of physicochemical characters,puerarin,baicalin berberine and glycyrrhizin in Gegen Qinlian Pellets.Methods Studies on improving the release rate of less soluble components in Gegen Qinlian Pellets were carried out and the parameters were optimized.The release profiles were analyzed by simulating factor(f_2).Results The f_2 values for baicalin,berberine and glycyrrhizin vs puerarin were 52.27,56.13,and 75.1,respectively.Conclusion The result shows that the same release rate of four index components in Gegen Qinlian Pellets is obtained.