Effect of rapamycin(RPM)on interleukin-10 gene expression in rats with postburn Staphylococcus aureus sepsis
- VernacularTitle:雷帕霉素对烫伤后金黄色葡萄球菌脓毒症大鼠白细胞介素10表达的影响
- Author:
Sheng YAO
;
Yongming YAO
;
Hongyun LI
;
Yan YU
;
Zhiyong SHENG
- Publication Type:Journal Article
- Keywords:
Sepsis;
Rapamycin;
Interleukin-10(IL-10);
Acute liver injury
- From:
Chinese Journal of Emergency Medicine
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of rapamycin(RPM)on hepatic interleukin-10(IL-10)gene and acute liver injury in rats with postburn Staphylococcus aureus sepsis.Methods Fifty male Wistar rats were randomly divided into four groups:normal control group,scald control group,postburn sepsis group,and RPM treatment group.Tissue samples from liver and plasma were collected to determine IL-10 mRNA and protein expressions,and liver function parameters were also measured.Results Compared to postburn Staphylococcus aureus sepsis group,in RPM treatment group hepatic IL-10 mRNA expression and plasma IL-10 were significantly increased at 0.5 hour after RPM treatment(P
