The study of optimal perfusion temperature of focal hypothermia in rats with traumatic brain injury
- VernacularTitle:局灶亚低温治疗创伤性脑损伤的最佳灌流温度
- Author:
Guangwei WANG
;
Yunsheng LIU
;
Youming LIANG
;
Hongtao QU
;
Chuanghua LI
- Publication Type:Journal Article
- Keywords:
Brain injuries;
Hypothermia;
Perfusion temperature
- From:
Chinese Journal of Emergency Medicine
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To find the optimal perfusion temperature of focal hypothermia in rats with traumatic brain injury(TBI).Methods Modified Feeney's free-falling model was used in the study.Forty-nine male Sprague-Dawley(SD)rats were randomly divided into seven groups:TBI group,systemic hypothermia group,focal hypothermia groups(including 0℃,10℃,20℃ or 25℃ subgroups,respectively)and control group.The contents of total sodium,potassium and water of traumatic brain were measured,and pathological changes were examined in the seven groups.Results The damaged neurons were significantly fewer in focal hypothermia groups(including 10℃,20℃ or 25 ℃ subgroups,respectively)than those in systemic hypothermia group at 72 hours after TBI(P
