Protective effect of 5-fluorouracil in rats with septic shock
- VernacularTitle:5-氟尿嘧啶对脓毒性休克大鼠的保护作用
- Author:
Lingjun LU
;
Nan XU
;
Xiaoli CHEN
- Publication Type:Journal Article
- Keywords:
5-fluorouracil;
Septic shock;
Animal model;
Pathology
- From:
Chinese Journal of Emergency Medicine
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of 5-fluorouracil(5-FU) on prognosis of septic shock in rats.Methods Thirty female Wistar rats was randomly divided into three groups: control group, septic shock group, and 5-FU group. The septic shock model was established by peritoneal injection of 1.8?109cfu/ml E. coli at the volume of 1 ml/100 g weight. The 5-FU group rats were treated intraperitonealy with 5-FU 50 mg/kg weight at 40 minutes after the septic shock model was established. All rats were killed at 6 hours after operation.The mortality, the ascites rate, the lung tissue wet weight and the lung injury score(LIS) were measured.Results The mortality, the ascites rate, the lung tissue wet weight and LIS of the septic shock group was 60%, 90%, (1.55?0.17)g,and(8.00?2.54),respectively. In 5-FU group, these parameters were 0, 10%, (1.36 ? 0.14) g,and(5.20?2.39),respectively. Compared with septic shock group, the mortality and the ascites rate of 5-FU group were significantly decreased, and the lung tissue wet weight and LIS were improved.Conclusion 5-FU can decrease the ascites rate, relieve inflammation and tissue damage.
