Counteractive Mechanism of Cyclovirobuxinum D for Myocardial Ischemia Induced by Pituitrin
- VernacularTitle:环维黄杨星D抗垂体后叶素致心肌缺血作用机理研究
- Author:
Jiuyao ZHOU
;
Rui LI
;
Xuezhen LIAO
;
Yingfeng ZHANG
- Publication Type:Journal Article
- Keywords:
CYCLOVIROBUXINUM D/pharmacology;
MYOCARDIAL ISCHEMIA/TCD therapy;
DISEASE MODELS, ANIMAL;
RATS
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2004;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To observe the counteractive action of cyclovirobuxinum D (Cvb-D) for myocardial ischemia and to explore its possible mechanism. [Methods] Sixty SD rats were randomized into blank control group, Cvb-D groups in the dosage of 2.2, 1.1 and 0.55 mg? kg-1 ? d-1 respectively, isosorbide dinitrate group (25 mg? kg-1 ?d-1). The blank control group was treated with distilled water and the other groups were treated with the corresponding drugs by gavage according to the experimental design for 30 days. One hour after the last medication, pituitrin (1.5 U/kg) was injected into the caudal vein of the rats except the blank control to induce coronary artery spasticity myocardial ischemia. After that, electrocardiogram (ECG) was recorded, plasma superoxide dismutase (SOD) activity, malonyldialdehyde (MDA), lactate dehydrogenase (LDH) and phosphocreatine kinase ( CPK) levels were detected. [ Results ] The incidence of ischemic changes in ECG was decreased, plasma SOD activity increased and MDA, LDH and CPK levels lowered in Cvb-D groups as compared with those in the model group (P
