Effect of Zhongfengkang on the Expression of AQP-4mRNA in Brain of Focal Cerebral Ischemia Rats
- VernacularTitle:中风康对局灶性脑缺血大鼠脑组织AQP-4mRNA表达的影响
- Author:
Muxiang YANG
;
Wentao YU
;
Fengzhe SU
;
Huazhou XU
- Publication Type:Journal Article
- Keywords:
Zhongfengkang;
Cerebral ischemia;
Aquaporin 4 mRNA;
Cerebral edema
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of Zhongfengkang on the expression of Aquaporin 4 mRNA(AQP-4mRNA) in brain of focal cerebral ischemia rats. Methods The rat model of focal cerebral ischemia was established by inserting nylon thread.The dynamic changes of AQP-4 mRNA expression in the model group at 12th,24th,48th,72nd and 96th hour after cerebral ischemia were examined and the effect of Zhongfengkang on AQP-4 mRNA expression and cerebral edema at 48 th hour after cerebral ischemia was observed.Results At 12th hour after cerebral ischemia,the expression of AQP-4mRNA in the model group increased compared with the sham-operation group,and it arrived to the peak at 72th hour(P
