Study of the complement 1q and its autoantibodies and their relationships with systemic lupus erythematosus and lupus nephritis
- VernacularTitle:补体C1q及抗C1q抗体与系统性红斑狼疮及狼疮肾炎相关性的研究
- Author:
Bin ZHOU
;
Fengchun ZHANG
;
Yi DONG
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus, systemic;
Lupus nephritis;
Complement 1q;
Autoantibodies;
Enzyme-linked mmunosorbent assay
- From:
Chinese Journal of Rheumatology
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the serum level of complement 1q (C1q) and anti-C1q autoantibodies (C1qAb) in systemic lupus erythematosus (SLE) patients to analyze the correlation of serum level of C1q and C1qAb with renal lesion and disease activity in SLE. Methods The serum level of C1q and C1qAb were detected by single radial lmnmnodiffusion and enzyme-linked immunosorbent assay respectively. Results The serum level of C1q in SLE patients was significantly lower than that of the control groups. The serum level of C1qAb in SLE patients was significantly higher than that of the control groups. There was a strong correlation between the serum level of C1q and C1qAb in SLE patients. SLE patients in flare stage showed a significantly higher level of serum C1qAb and a lower level of serum C1q than stable patients. Lupus nephritis(LN) patients showed a significantly higher level of serum C1qAb and a lower level of serum C1q than non-LN patients. Conclusions Low level of serum C1q and the high level of serum C1qAb are correlated with SLE. The serum level of C1q and C1qAb are significantly correlated with renal lesion and disease activity of SLE patients.
