Study on Expression of ANP63 and HPV16 E7 in Cervical Intraepithelial Neoplasia
- VernacularTitle:宫颈癌前病变中?NP63与HPV16 E7表达的研究
- Author:
Ying JIA
- Publication Type:Journal Article
- Keywords:
cervical intraepithelial neoplasia;
(?)NP63;
HPV16 E7
- From:
Journal of Chongqing Medical University
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
objective: To examine the potential of ANP63 and HPV16 E7 as one of biomarkers for cervical premalignant lesions in Thi-nPrep smears, and to search for the identification of specific biomarkers for cervical intraepithelial neoplasia (CIN) as a new examining method to evaluate evolution of CIN. Method; Streptavidin peroxidase (SP) method was used. Immunocytochemical analysis of ANP63 expression was performed in 71 ThinPrep smears. RT - PCR was used to detect the mRNA of HPV16 E7 in 71 ThinPrep liquid - based smears specimens. Result; Positive expression rate of ANP63 in CIN was higher than that in inflammation (P
