Application of uniform design for preparation of Breviscapine Liposomes
- VernacularTitle:应用均匀设计法对灯盏花素纳米脂质体的处方优化
- Author:
Weiwei TIAN
;
Qingfei LIU
;
Guoan LUO
;
Yiming WANG
- Publication Type:Journal Article
- Keywords:
uniform design;
breviscapine;
liposomes;
optimum preparation
- From:
Chinese Traditional Patent Medicine
1992;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To optimize the formulation in the preparation of the Breviscapine Liposomes. METHODS: Using film evaporation-extrusion method to prepare Breviscapine Liposomes according to the uniform design,a optimum formulation was established by determining the entrapment efficiency and the ratio of loading drug. RESULTS: The entrapment efficiency and the ratio of loading drug of Breviscapine Liposomes prepared with cholesterol and lecithin were determined to be 69.60% and 29.06%,respectively.The average diameter is 105.6 nm. CONCLUSION: The application of the uniform design is useful to achieve a large entrapment efficiency and ratio of loading drug.
