The mechanism underlying the analgesic effect of the iontophoresis of aconitine on the adjuvant arthritis in rat
- VernacularTitle:乌头碱直流电离子导入对大鼠关节炎的镇痛作用及其机制探讨
- Author:
Le KANG
;
Shouwei YUE
;
Xiaoling WANG
;
Ming FANG
- Publication Type:Journal Article
- Keywords:
Aconitine;
Iontophoresis;
Arthritis;
5-HT;
NE;
?-EP
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the mechanism of analgesic effects of the iontophoresis of aconitine on the rat with adjuvant arthritis. Methods Forty-five Wistar rats were randomly divided into a normal control group, a model group and a therapy group, with 15 rats in each group. The model of rat adjuvant arthritis(AA) was induced by injection of complete Freud′s adjuvant(0.1 ml) into the right ankle joint of the rats. The brain stem, hypothalami and local inflammation tissue of rats in the 3 groups were obtained after 1, 5 and 10 days of treatment, respectively. The concentrations of 5-HT, NE, ?-EP in brain stem, hypothalami and local inflammation tissue were detected with high performance liquid chromatography (HPLC) and radioimmunoassay (RIA). Results It was shown that the 5-HT content in the inflammatory tissues was not significantly different from that in the model group after 1 day of treatment, but significantly lower than that in the model group after 5 to 10 days of treatment (P0.05). After 5 to 10 days of treatment, the brain stem NE content in the therapy group was significantly higher than that in the model group(P
