Clinical analysis for five cases of primary hypothyroidism with main manifestations of muscular damage
- VernacularTitle:以肌损害为主要表现的原发性甲状腺功能减退症五例
- Author:
Ling HU
;
Jie QIN
;
Jie LIU
- Publication Type:Journal Article
- Keywords:
Hypothyroidism;
Myopathy;
Creatine kinase;
Polymyositis;
Diagnosis,differential
- From:
Chinese Journal of General Practitioners
2005;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To improve the understanding of clinical features,pathological changes and therapy in patients of severe primary hypothyroidism accompanied with myoapthy.Methods Clinical features and prognosis of five cases of primary hypothyroidism accompanied with severe myopathy admitted to the hospital during March 1996 to November 2003 were anaylzed retrospectively by medical records combined with review of relevant literatures.Results Prominent clinical manifestations of the five patients were muscular damage,symmetrical proximal weakness of the muscles(myasthenia),shortness of breath,chest pain,dysphagia,and significant increase in activity of serum creatine phosphokinase(2 885~10 450(U/L).)Conclusions Patients of primary hypothynoidism with muscular damage should be diffrentiated from those of polymyositis and better effectiveness can be achieved for its related myopathy by timely thyroid hormone replacement therapy.
