Molecular mechanism of activator protein-1 and macrophage inflammatory protein-1? in adjuvant arthritis rats and the effects of sodium arsenite
- VernacularTitle:活化蛋白-1和巨噬细胞炎性蛋白-1?在实验性关节炎大鼠发病中的分子机制及亚砷酸的影响
- Author:
Long LI
;
Jiashun ZENG
;
Yingqiang CHEN
- Publication Type:Journal Article
- Keywords:
Arthritis, experimental;
Macrophage inflammatory protein-1;
Activator protein-1;
Arsenites
- From:
Chinese Journal of Rheumatology
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the molecular mechanism of activator protein (AP)-1 and macrophage inflammatory protein (MIP)-1? in adjuvant arthritis and the effects of sodium arsenite (SA) on AP-1 and MIP-1. Methods Forty Wistar female rats were randomly divided into 4 groups: normal control (NC), model (M), low concentration sodium arsenite (SA1) and high concentration sodium arsenite group (SA2). The SA1 group and the SA2 group were treated with sodium arsenite (0.5 mg?kg-1?d-1 and 1.0 mg?kg-1?d-1) through abdominal cavity injection for 20 days, the normal control group and the model group were treated with saline (0.2 ml/d). The levels of C reactive protein (CRP) in every group were determined by biochemistry, the C-fos and MIP-1? expression of synovium in 4 groups were determined by immunohistochemistry. Results The levels of CRP in the M group were increased more than NC group (P
