Effect of early intervention on bone mass and biomechanical properties of femur in rats after spinal cord injury
- VernacularTitle:脉冲电磁场及阿仑膦酸钠对脊髓损伤大鼠骨质量的影响
- Author:
Fang CONG
;
Shurong JI
;
Hongjun ZHOU
- Publication Type:Journal Article
- Keywords:
Spinal cord injury;
Osteoporosis;
Alendronate;
Pulsed electromagnetic fields
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of early administration of alendronate (ALN) and pulsed electromagnetic fields (PEMFs) on bone mass of rats after spinal cord injury(SCI). Methods Sixty-two healthy female SD rats aged 3 months were randomly allocated into 5 groups: a Sham group, a SCI group, a SCI+ALN group, a SCI+PEMFs group and a SCI+PEMFs+ALN group. Rats in the Sham group underwent laminectomy, while the rats in the other 4 groups underwent complete spinal cord transection, and the remained 3 groups were treated with ALN and/or PEMFs 1 week after SCI. All rats were sacrificed 8 weeks after operation. The bone mineral density(BMD), biomechanical parameters of the femurs, and histomorphometric parameters of proximal tibias were mea-sured, respectively. The data were analyzed with one way-ANOVA and factorial design-ANOVA. Results After early treatment of ALN and/or PEMFs, the BMD of femur was significantly increased as compared with that of rats in the SCI group; the elastic load, maximal load of femur were significantly increased as compared with those of rats in the SCI group; the percent trabecular bone area and trabecular bone width of tibias were significantly increased when compared to those of rats in the SCI group. Conclusion Early treatments of ALN and PEMFs can reduce the loss of bone, improve biomechanical properties of the femur, and inhibit the decay of microstructure of upper part of tibia. The study suggests that ALN and PEMFs may help prevent osteoporosis after SCI.
