Expression of estrogen and progesterone receptor subtypes in human endometrial carcinoma tissues
- VernacularTitle:子宫内膜癌组织中雌激素及孕激素受体亚型的表达研究
- Author:
Qinping LIAO
;
Cheng WU
;
Hong ZHENG
;
Li YU
- Publication Type:Journal Article
- Keywords:
Receptors, estrogen;
Receptors, progesterone;
Endometrial neoplasms
- From:
Chinese Journal of Obstetrics and Gynecology
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of estrogen receptor (ER) and progesterone receptor (PR) subtypes in human endometrial carcinoma tissues. Methods Thirty samples of normal endometrial tissue and 66 endometrial carcinomas were investigated using western blot assays and reverse-transcription polymerase chain reaction. Results (1)Both ER? and ER? mRNA were significantly increased in endometrial carcinoma compared with that in normal endometrium tissues. The relative value of ER? and ER? mRNA in endometrial carcinoma was 8.00?7.77, 3.84?2.57 and that in normal endometrium tissues was 4.15?3.55, 0.41?0.29, respectively. (2) Decreased levels of PR, PRA, PRB protein and PR mRNA were associated with endometrium carcinogenesis (P
