Effect of Taohong Siwu DecoctionⅡon Inhibiting the Agiogenesis and KDR/FLK-1 Expression
- VernacularTitle:桃红四物汤Ⅱ号抗血管生成作用及其对KDR/FLK-1表达的影响
- Author:
Xiaoyu XU
;
Shumei WANG
;
Weihai CHEN
;
Gang CHEN
- Publication Type:Journal Article
- Keywords:
Taohong Siwu DecoctionⅡ;
Anti-agiogenesis;
KDR/FLK-1
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2000;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the anti-agiogenesis effect of Taohong Siwu Decoction Ⅱ(THSDⅡ)and to explore its mechanism.Methods Chicken Chorioallantoic Membrane(CAM)assay was used to study the anti-agiogenesis action of THSDⅡin vivo.MTT assay was used to investigate its effect on the proliferation of human umbilical vein vascular endothelial cells ECV304 in vitro.Immunohistochemistry assay was used to observe its effects on the expression of KDR/FLK-1 in endothelial cells and the amount of micro-vessel density(MVD)in mice with B16 melanoma.Results THSDⅡ at the dosages of 1 g / mL and 2 g / mL could obviously inhibit agiogenesis in the CAM(P
