High Toxoplasma gondii Seropositivity among Brain Tumor Patients in Korea.
10.3347/kjp.2016.54.2.201
- Author:
Bong Kwang JUNG
1
;
Hyemi SONG
;
Min Jae KIM
;
Jaeeun CHO
;
Eun Hee SHIN
;
Jong Yil CHAI
Author Information
1. Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine, Seoul 03080, Korea. cjy@snu.ac.kr
- Publication Type:Brief Communication
- Keywords:
Toxoplasma gondii;
seroprevalence;
brain tumor;
ELISA
- MeSH:
Brain Neoplasms*;
Brain*;
Enzyme-Linked Immunosorbent Assay;
Humans;
Incidence;
Korea*;
Meningioma;
Seroepidemiologic Studies;
Toxoplasma*;
Tumor Microenvironment
- From:The Korean Journal of Parasitology
2016;54(2):201-204
- CountryRepublic of Korea
- Language:English
-
Abstract:
Toxoplasma gondii is an intracellular protozoan that can modulate the environment of the infected host. An unfavorable environment modulated by T. gondii in the brain includes tumor microenvironment. Literature has suggested that T. gondii infection is associated with development of brain tumors. However, in Korea, epidemiological data regarding this correlation have been scarce. In this study, in order to investigate the relationship between T. gondii infection and brain tumor development, we investigated the seroprevalence of T. gondii among 93 confirmed brain tumor patients (various histological types, including meningioma and astrocytoma) in Korea using ELISA. The results revealed that T. gondii seropositivity among brain tumor patients (18.3%) was significantly (P<0.05) higher compared with that of healthy controls (8.6%). The seropositivity of brain tumor patients showed a significant age-tendency, i.e., higher in younger age group, compared with age-matched healthy controls (P<0.05). In conclusion, this study supports the close relationship between T. gondii infection and incidence of brain tumors.
