Effect of Bidouyan Oral Liquid for the Treatment of Experimental Suppurative Maxillary Sinusitis Rabbits
- VernacularTitle:鼻窦炎口服液治疗家兔实验性上颌窦炎
- Author:
Dajing XIONG
;
Hui XIE
;
Pingping LIU
;
Suru LIU
- Publication Type:Journal Article
- Keywords:
Bidouyan Oral liquid;
Acute suppurative maxillary sinusitis;
White blood cells count;
C-reactive protein;
Bacteria culture
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2000;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the therapeutic effect of Bidouyan Oral Liquid(BOL) on acute suppurative max-illary sinusitis(ARMS) in rabbits.Methods Modified Hinni's method was used to inducing the ARMS rabbit models.The high and low-dosage of BOL was administered by gastric gavage and penicillin V was used for the positive medicine.The white blood cells(WBC)count,neutrophil percentage,serum C-reactive protein(CRP)level,inflammatory changes of mucosa of nasal sinuses under light microscope and bacteria culture of secretion in ARMS rabbit models were observed.Results Inflammatory changes were shown in the experimental ARMS rabbits as follows:white blood cells count and neutrophil percentage increased,mucosa of nasal sinuses congested and swollen with the exfoliation of pili.After the treatment with high-and low-dosage of BOL,the above parameters in the rabbits recovered to normal,the difference being insignificant compared with penicillin V.Conclusion BOL in clinical dose can control the general and local inflammatory reaction in ARMS rabbits.
