An Experimental Study of Phyllanthus urinaria for Counteracting Immune Liver Injury in Mice
- VernacularTitle:福建叶下珠抗小鼠免疫性肝损伤的实验研究
- Author:
Tianbao FENG
;
Guangjun TIAN
;
Hua LI
;
Mingzeng TANG
;
Peiqiong CHEN
;
Xinhua WANG
;
Fengxue ZHANG
- Publication Type:Journal Article
- Keywords:
Phyllanthus urinaria;
lmmune liver injury;
Bacillus Calmette-Guerin vaccine;
Lipopolysaccharide;
Mice
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2000;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the protective action of Phyllanthus orinaria(PU)for immune liver injury in mice.Methods Forty-eight NIH mice were allocated randomly to high-dose(HG)PU group,low-dose(LG)PU group,bifenbate group(BG),normal control group(NCG),and model group(MG).From the first day of establishing the models,20 g ? kg-1 of PU solution was given for gastric perfusion(GP)to HG PU group,10 g ? kg-1 of PU solution for GP to LG PU group,0.15 g?kg-1 of bifenbate solution for GP to BG group,and the equal amount of normal saline to the normal control group and the model group,qd for 12 days.Serum ALT level and visceral parameters of liver and spleen were determined,and the liver pathological feature was also examined.Results The ALT level,parameters of liver and spleen were markedly decreased in BG group(P 0.05).Conclusion PU has a good effect on counteracting the immune live injury in mice by markedly decreasing the activity of serum transaminase and visceral parameters of liver and spleen,and improving the necrosis of hepatic cells.
