Studies on the Extraction of Volatile Oil in Leifengguan Granules and the Preparation of Their ?-CD Inclusion Compounds
- VernacularTitle:类风关颗粒中挥发油的提取及-?CD包合工艺研究
- Author:
Ruihai WANG
;
Zhizhong LIU
;
Limei LIU
;
Lin CHEN
- Publication Type:Journal Article
- Keywords:
Leifengguan Granules;
Fructus Tsaoko;
Radix Saposhnikoviae;
Extraction of Volatile Oil;
?-CD inclusion compounds;
Orthogonal Test
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2000;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To optimize the conditions for the extraction of volatile oil from Fructus Tsaoko and Radix Saposhnikoviae in Leifengguan granules,and for the preparation of their ?-CD inclusion compounds.Methods With the percentages of extracted volatile oil of Fructus tsaoko and Radix saposhnikoviae as the target marker,single-element experiments were conducted to determine the optimum conditions for extracting the volatile oil.The application rate of included volatile oil was used as the target marker to optimize the conditions for including the oils with ?-CD.Results The optimized extraction conditions were: with 8-fold water added,the sliced herbal medicine of Fructus tsaoko and Radix saposhnikoviae should be extracted for six hours without advanced soaking with water.The optimized inclusion conditions were: applying the saturated aqueous solution method,15-fold 85 % ethanol was used to dissolve the volatile oil,the proportion of the above solution and ?-CD being 1︰8;at 25 ℃,the volatile oil was included for 30 minutes with ultrasonic wave.Conclusion The established process can be used for the extraction and the inclusion of volatile oil from Fructus Tsaoko and Radix Saposhnikoviae in Leifengguan granules.
