Effect of Yangyin Kangdu Powder on Peripheral Blood T-lymphocyte Subsets in X-ray-irradiated Mice
- VernacularTitle:养阴抗毒散对X线照射小鼠外周血T淋巴细胞亚群的影响
- Author:
Yuan LU
;
Dacan CHEN
;
Junfeng HOU
;
Guowei XUAN
- Publication Type:Journal Article
- Keywords:
YANGYIN KANGDU POWDER/pharmacology;
RADIATION INJURIES/TCD therapy;
RADIATION INJURIES/immunology;
DISEASE MODELS, ANIMAL;
MICE
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To investigate the effects of Yangyin Kangdu Powder (YKP) on peripheral blood T-lymphocyte subsets levels in X-ray-irradiated mice. [Methods] Forty-five mice were randomized into normal control, model and YKP groups. Except the normal group, the rats in model and YKP groups were irradiated with 6Gy X-ray to establish models with acute radiation-induced injury. Normal saline was given to the model group while YKP in the dosage of 10 g?kg-1?d-1 was orally administered to YKP group for one week. The changes of CD4 and CD8 T-lymphocyte subsets levels were detected by flow cytometry. [Results] Plasma levels of CD4 and CD8 and the ratio of CD4/CD8 decreased in the model group, the difference being significant as compared with the normal control group (P
