The experiment research of amino in neurotoxin from agkistrodon
- VernacularTitle:蝮蛇神经毒素氨基的实验研究
- Author:
Youdong WEI
- Publication Type:Journal Article
- Keywords:
Neurotoxin;
Amino;
The experimental research
- From:
Journal of Chongqing Medical University
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To modify amino in the neurotoxin,learn about modified neurotoxin′s activity.Methods:We made rat models that were suffered from spinal injury and had marked muscular hypertonia.We separated neurotoxin from agkistrodon in ZheJiang,modified amino in the neurotoxin by using acetic anhydride,then applied the modified neurotoxin to rats in order to know about its effects,and used the physiological recorder to authenticate its effects.Results:The modified neurotoxin was applied to the rats by injecting to the abdominal cavity.These rats 'muscular hypertonia was improved,and their survival time was much longer.Conclusion:Amino in the neurotoxin is an important radical.
