Correlation of estrogen receptor expression to activity of cell proliferation and chincopathology in brain tumors
- VernacularTitle:ER在脑肿瘤中的表达与细胞增殖和临床病理的关系
- Author:
Shunhe WANG
- Publication Type:Journal Article
- Keywords:
Estrogen receptor(ER);
Astrocytomas;
Proliferating cell nuclear antigen(PCNA);
Immunohistochemistry
- From:
Journal of Chongqing Medical University
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the correlation of ER expression to the activity of cell proliferation and clinicopathology in brain tumors(astrocytomas,ependynomas,and medulloblastomas).Methods:The expression of ER and proliferating cell nuclear antigen(PCNA) were determined by SP immunohistochemical method in 64 cases of brain tumors tissues.Correlation ER expression with chinicopathological characteristics was studied.Results:The positive rates of ER expression in astrocytomas,ependynomas,and medulloblastomas were 39.47%(15/38),35.71%(5/14) and 41.60%(5/12) respectively.Maliganat astrocytomas(42.8%) had a significantly higher ER expression rate compared with Benign astrocytomas(33.3%)(P
