Effect of Lovastatin preconditioning on cardiac myocyte apoptosis in ischemic and reperfused rat hearts
- VernacularTitle:洛伐他汀预处理对大鼠急性心脏缺血再灌注中心肌细胞凋亡的影响
- Author:
Xiaojie ZHANG
;
Zongquan SUN
;
Xinling DU
- Publication Type:Journal Article
- Keywords:
Myocardial reperfusion injury Apoptosis Lovastatin Animal testing alternatives
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
1995;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects and mechanisms of Lovastatin preconditioning on cardiac myocyte apoptosis in acute ischemic and reperfused (I/R) rat hearts. Methods 24 Sprague-Dawley male rats were randomly divided into three groups: control group (C); Lovastatin group (L) treated with lovastatin 15 mg/kg once a day for two weeks; Lovastatin and L-NAME group (N) treated with the same dose of Lovastatin with L group and L-NAME 30 mg/kg once a day for two weeks. Rat heart models of I/R were established with coronary occlusion 30 mintues and reperfusion 30 mintues of the left anterior descending artery after two-week administration. Expression of Bcl-2,Bax protein and myocardium apoptosis were investigated in every group. Results There was no change in blood lipin, expression of Bax protein was increased (P
