Preparation of Gegen Qinlian Pellets by extrusion-spheronization method
- VernacularTitle:挤出滚圆法制备葛根芩连微丸
- Author:
Qingpo LI
;
Jian YOU
;
Lei YANG
;
Ying ZHAO
;
Yongsheng WANG
;
Fude CUI
- Publication Type:Journal Article
- Keywords:
Gegen Qinlian Pellets;
extrusion-spheronization method;
preparation
- From:
Chinese Traditional and Herbal Drugs
1994;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare Gegen Qinlian Pellets with higher yield of drug loading and being good for industrial production.Methods The Gegen Qinlian Pellets were prepared by extrusion-spheronization.The effects of four key parameters on spheronization process were the proportion of bond,extrusion speed,spheronisation speed,and spheronisation time,which were investigated to obtain optimal formulation.Results Gegen Qinlian Pellets presented perfect sphericity and narrow diameter distribution.Drug loading in the pellets could be up to 70% and yelid over 90%.Conclusion The Gegen Qinlian Pellets are successfully prepared by extrusion-spheronization.It presents a method for industria-lized production of Chinese materia medica.
