Expression and significance of nuclear transcription factor in myocardium of rheumatic heart disease
- VernacularTitle:风湿性心脏病心肌中核转录因子的表达及其意义
- Author:
Chonglei REN
;
Weiyong LIU
;
Jinbao ZHANG
- Publication Type:Journal Article
- Keywords:
Rheumatic heart disease;
Myocardium;
Collagen;
NF-kappaB;
Transcripition factor AP- 1
- From:
Chinese Journal of Rheumatology
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of nuclear transcription factor- kappa B (NF-!B) and activated protein- 1 (AP- l) on rheumatic myocardial fibrosis. Methods Thirty rheumatic myocardial specimens and 10 normal samples were examined by Masson′s staining, immunohistochemical staining and image analy- sis. Results Both NF- !B and AP- 1 were expressed in the nuclei of myocardium with rheumatic heart disease (RHD). The degree of positive staining in myocardiurn with RHD was significantly correlated with the cardial collagen volume (NF-!B: r=0.8945, AP- 1: r=0.9011, P
