Determination of impurity in ephedrine hydrochloride and pseudoephedrine hydrochloride by HPLC
- VernacularTitle:HPLC法测定盐酸麻黄碱和盐酸伪麻黄碱中杂质
- Author:
Xiangdong LIU
;
Qionglin LIANG
;
Guoan LUO
;
Yiming WANG
;
Qingfei LIU
- Publication Type:Journal Article
- Keywords:
ephedrine hydrochloride (E);
pseudoephedrine hydrochloride (PE);
HPLC;
impurity
- From:
Chinese Traditional and Herbal Drugs
1994;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
0.999). The relative standard deviation (RSD) of chromatogram area was less than 1.0% for all of them after six successive injections. The detection limit was 0.05 ?g/mL for norephedrine (NE), 0.04 ?g/mL for norpseudoephedrine (NPE), 0.1 ?g/mL for E and PE, and 0.2 ?g/mL for mephedrine (ME) and mepseudoephedrine (MPE), respectively (S/N≥3). The recovery rate was more than 97.1% for six ephedrine alkaloids. Under this method system, all of the above-mentioned six samples were tested and found to contain some of the impurity at different levels. Conclusion This developed method, which is very simple, perfect precision, high sensitivity, and selectivity, can be used for the qualitative and quantitative determination of impurities of ephedrine alkaloid-type samples.
