Pharmacokinetics of recombinant hirudin in rats in vivo
- VernacularTitle:重组水蛭素在大鼠体内的药动学研究
- Author:
Yurong HUANG
;
Quansheng LI
;
Changxiao LIU
- Publication Type:Journal Article
- Keywords:
recombinant hirudin (r-hirudin);
radioactivity;
pharmacokinetics
- From:
Chinese Traditional and Herbal Drugs
1994;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
brain and fatty. The accumulation excretion ratios within 96 h were 70.16% in urine and only 1.35% in feces after iv administration in rats, while within 24 h was 3.46% in bile. Conclusion The results of pharmacokinetics of novel r-hirudin in rats given by iv determined by RA are different from those determined by TCA-RA, but the trends indicated by the two methods are the same; urine excretion is the major excretion pathway.
