Effects of Cryptoporus volvatus ferment substance on airway hyperresponsiveness and inflammation in asthmatic mice with spleen-deficiency syndrome
- VernacularTitle:隐孔菌发酵物对脾虚证哮喘小鼠气道高反应性及炎症的影响
- Author:
Zhaosheng BAO
;
Hequan LI
;
Chuansen SHAO
;
Hui ZHANG
;
Qiangmin XIE
- Publication Type:Journal Article
- Keywords:
Cryptoporus volvatus (Peck) Hubbard ferment substance (CVFS);
spleen-deficiency syndrome;
asthma;
airway hyperresponsiveness
- From:
Chinese Traditional and Herbal Drugs
1994;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a model of asthma mice with spleen-deficiency syndrome (asthma-SDS) and to investigate the effects of Cryptoporus volvatus ferment substance (CVFS) on the airway hyperresponsiveness and inflammation in model mice. Methods An asthma-SDS model of mice was established by ovalbumin (OVA)-sensitized plus over-eating and over-exerting. The changes of lung resistance (R_L), inflammatory cells in bronchoalveolar lavage fluid (BALF), lung tissue pathology, and spleen index were observed. Results Compared with the simple asthma model of mice, the airway hyperresponsiveness, eosinophils number in the BALF, lung tissue pathology, and spleen index in the asthma-SDS model of mice showed a significant difference (P
