Effect of combined oxaliplatin and capecitabine chemotherapy on advanced and recurrent gastric cancer

VernacularTitle:奥沙利铂联合卡培他滨治疗晚期及复发转移性胃癌的临床观察
Author: Bo PENG
Publication Type:Journal Article
Keywords: Stomach neoplasms; Neoplasm metastasis; Drug therapy,combination
From: Cancer Research and Clinic 2011;23(4):254-255,258
CountryChina
Language:Chinese
Abstract: Objective To investigate the therapeutic effect and side effect of combined capecitabine with oxaliplatin on advanced and recurrent gastric cancer.Methods 56 patients with advanced and recurrent gastric cancer were treated with combined oxaliplatin and capecitabine chemotherapy,and the therapeutic effect and side effect were analyzed retrospectively.Results Among all 56 patients treated with combined oxaliplatin and capecitabine chemotherapy,4 patients (7.1%) were complete remission,26 patients (46.4 %)were partial remission,20 patients (35.7 %) were stabilization,6 patients (10.7 %) were progression,and the response rate was 53.6 %.The median remission time was 7.8 months,and the median survival time was 11.3 months.The main side effects were nausea and vomiting,diarrhea,hand-foot syndrome,peripheral nerve toxicity,transaminase increasing and leuco cytopenia,however,the side effects were mainly grade Ⅰ and Ⅱwhich could be tolerated by patients.Conclusion The combined oxaliplatin and capecitabine chemotherapy is an effective method and has better tolerance in treatment of advanced gastric cancer and is well worth clinical application.