Expression of cytosolic phospholipase A2, 5-lipoxygenase and LTC4 synthetase mRNA in the peripheral polymorphonuclear leukocytes of patients with systemic lupus erythematosus
- VernacularTitle:系统性红斑狼疮患者外周血多形核粒细胞磷脂酶A25-脂氧化酶和白三烯C4合成酶mRNA的表达
- Author:
Zusen XU
;
Yuan LIANG
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus, systemic;
Reverse transcriptase polymerase chain reaction;
Neutrophils;
Cytosolic phospholipase A2;
5-lipoxygenase;
LTC4 synthetase
- From:
Chinese Journal of Rheumatology
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05, both). The mean levels of 5-LO and LTC4-S mRNA expression in active SLE group were significantly higher than those in normal controls respectively (P0.05). Conclusion The levels of 5-LO and LTC4-S mRNA expression in active SLE group increase markedly, which may be involved in the pathogenesis of SLE and provide a valuable scientific basis for the clinical use of specific 5-LO inhibitors and cysteinyl leukotrienes receptor antagonists.
