Effect of Lycium Bar bar um Polysaccharide on T-lymphocyte Subsets and Dendritic Cells in H_(22)- bearing Mice
- VernacularTitle:枸杞多糖对荷瘤小鼠淋巴细胞亚群及树突状细胞表达的影响
- Author:
Yanli HE
;
Yi YING
;
Rongjing LUO
;
Bin WANG
;
Biaoyan DU
;
Hui LUO
- Publication Type:Journal Article
- Keywords:
LYCIUM BARBARUM POLYSACCHARIDE/pharmacology;
NEOPLASMS/TCD therapy;
NEOPLASMS/immunology;
DISEASE MODELS, ANIMAL;
MICE
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To investigate the effect of Lycium barbarum polysaccharide (LBP) on T-lymphocyte subsets levels, dendritic cells (DCs) counting and antigen CD80 expression in peripheral blood and tumor stroma of H22-bearing mice. [Methods] H22-bearing mice models were established. LBP in the dosages of 1.25 and 0.625 g?kg-1?d-1 was orally administered to the mice models for two weeks. The changes of T-lymphocyte subsets levels, DCs counting and antigen CDgo expression in peripheral blood and tumor stroma were detected by flow cytometry (FCM) . [ Results ] LBP increased the numbers of CD4+ and CD8+ T-cells, promoted the proliferation of CD4+ T-cells, and elevated the ratio of CD4+ /CD8+ in peripheral blood. LBP in large dosage also increased the numbers of CD4+ and CD8+ T-cells in the tumor-infiltrating lymphocytes (P
