Stability of ligustilide and its ?-cyclodextrin inclusion process
- VernacularTitle:藁本内酯的稳定性及?-环糊精包合工艺的考察
- Author:
Hui LI
- Publication Type:Journal Article
- Keywords:
ligustilide;
stability;
?-cyclodextrin inclusion process
- From:
Chinese Traditional and Herbal Drugs
1994;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the stability of ligustilide and the inclusion process in ?-cyclodextrin to avoid its isomerization.Methods The content of ligustilide dropped severely even if it was kept away from layer and air under room temperature.The inclusion process with ?-cyclodextrin was carried out on orthogonal design.The optimum conditions were determined and inclusion complex was made sure by many ways.Results The validated trials by DCS,IR,and GC could exhibit the obvious difference between mixture and inclusion complex which showed the form of a new phase,because of ?-cyclodextrin and drugs in the molecular capsules.Conclusion Inclusion process with ?-cyclodextrin can improve stability of ligustilide that is unstable in normal situation.
