Detection of Fas on colonic apoptosis epithelium in ulcerative colitis by double staining immunohistochemistry
- VernacularTitle:双重酶标法检测溃疡性结肠炎凋亡上皮细胞Fas的表达
- Author:
Jin YAN
- Publication Type:Journal Article
- Keywords:
Ulcerative colitis;
Double staining IHC;
Fas;
Apoptosis
- From:
Journal of Chongqing Medical University
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To discuss the role of Fas/FasL-mediated colonic epithelial apoptosis in the pathogenesis of ulcerative colitis(UC).Methods:Expression of Fas,FasL and M30(a new epithelium apoptosis marker) antigen on colonic mucosa of 35 patients with UC and 15 control populations were detected by IHC.Each marker was analyzed by image analysis system.Co-expression of Fas and M30 was observed through serial sections and double staining IHC.Results:The expression of Fas,FasL as well as M30 in UC increased considerably compared with controls (P
