An experimental study on the effect of somatostatin in antagonizing the maladjustment of sexual hormones homeostasis induced by tamoxifen
- VernacularTitle:生长抑素逆转三苯氧胺对性激素内环境影响的实验研究
- Author:
Xizhi ZENG
- Publication Type:Journal Article
- Keywords:
Octreotide;
Tamoxifen;
Experimental mammary carcinoma
- From:
Journal of Chongqing Medical University
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of somatostatin (SST) analog octreotide (OCT) in antagonizing the maladjustment of sexual hormones homeostasis induced by tamoxifen(TAM) in rat.Methods:Eight weeks after DMBA(a single dose 100mg/kg body weight by subcutaneous injection) application,the female Wistar rats were randomized to control and treatment groups.Rats in treatment groups underwent TAM(1mg/kg 5 times weekly for 14 weeks by subcutaneous injection),OCT(0.1mg/kg bid for 14 weeks by subcutaneous injection),or the combination of both.The levels of sexual hormones (estradiol,progesterone,prolactin,follicle stimulating hormone,luteinizing hormone) were assessed by enzyme immunoassay(EIA).Results:The levels of estradiol and progesterone in serum were remarkably higher in TAM group(21.69pg/ml,6.14ng/ml) than in control group(16.92pg/ml,4.13ng/ml) respectively(P
