The inhibitory effect of cyclooxygenase inhibitor on human breast cancer line MDA-MB-231 in vitro
- VernacularTitle:环氧化酶抑制剂对人乳腺癌细胞株MCF-7的抑制作用研究
- Author:
Fangxin LIU
- Publication Type:Journal Article
- Keywords:
Cyclooxygenase inhibitor acetylsalicylic acid;
Selective COX-2 inhibitor;
Human breast cancer cell line MDA-MB-231
- From:
Journal of Chongqing Medical University
1986;0(04):-
- CountryChina
- Language:Chinese
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Abstract:
Objective:To investigate the inhibitory effect of cyclooxygenase inhibitor acetylsalicylic acid(ASA),and a selective COX-2 inhibitor(Nimesulide) on the growth of human breast cancer cell line MDA-MB-231 in vitro.Methods:The inhibitory effect was detected by MTT assay.Immunohistochemical assay was performed to examine the expressions of COX-2 and c-erbB-2 in SKOV3 cell line treated by NSAIDs.Results:A decrease in cell number compared with controls was observed in all of the cell line treated with ASA and Nimesulide.It was a dose-dependent inhibition of cell proliferation.COX-2 was expressed positive in MDA-MB-231 and the expression of cerbB-2 was found to decrease by immunohistochemical assay.Conclusion:NSAIDs can inhibit the growth of human breast cancer cell line MDA-MB-231 in vitro.
