Acute toxicity of Xidan Suspensions in mice
- VernacularTitle:抗癌中药希丹液的急性毒性作用研究
- Author:
Wenhua RAN
- Publication Type:Journal Article
- Keywords:
Xidan suspensions;
Toxicity;
Mice
- From:
Journal of Chongqing Medical University
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study acute toxicity of Xidan suspensions in mice.Methods:To measure the LD50 and to observe the response to machinery stimulation and the autonomic activity of the experimental animals when Xidan suspensions is taken orally into the mice.Results:The LD_(50) of Xidan suspensions is 148.08g(crude medicinal materials)/kg in the mice by ig.When it is taken orally(ig)into the mice at the dosage of LD_(50) or more [180g(crude medicinal materials)/kg],it is found that the response to machinery stimulation,the autonomic activity the muscle tone and the regulation of balance ability decreased obviously.Conclusion:It is indicated that Xidan suspensions could be toxic to the nervous system of mice.
