Effects of low frequency electric stimulation at bilateral mastoid processes on focal cerebral ischemia-reperfusion in rats
- VernacularTitle:双乳突法低频电刺激对大鼠局灶性脑缺血再灌注损伤的影响
- Author:
Jihong ZHOU
;
Zhiqiang ZHANG
;
Xiuhua YUAN
- Publication Type:Journal Article
- Keywords:
Low frequency electric stimulation, Mastoid process;
Focal cerebral ischemia;
Ischemia-reperfusion;
Brain edema
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the protective effects of low frequency electric stimulation at bilateral mastoid processes on the focal cerebral lesion induced by ischemia-reperfusion in rats. Methods Focal cerebral ischemia in rats was produced by 2 hours of the middle cerebral artery occlusion (MCAO) and 24 hours reperfusion. The neurological deficits scale was used to evaluate and screen the rats for tests. The cerebral water content was determined by wet/dry weighing method. The infarct volume was measured by 2,3,5-triphenyltetrazolium chloride (TTC) staining technique and image analysis instrument. The activity of superoxide dismutase (SOD) and the content of malondialdehyde (MDA) in ischemic tissue of brain were analyzed. Results Compared with the control group, the severity of cerebral edema in the treatment group, apart from the emergency group,was lessened(P
