Effect of continuous passive motion in prevention of osteoarthritis induced by experimental articular cartilage injury
- VernacularTitle:不同的持续被动运动时间对软骨损伤后发生骨性关节炎的影响
- Author:
Chunna LAN
;
Changjie ZHANG
;
Gang WU
;
Weixiong CHEN
- Publication Type:Journal Article
- Keywords:
Cartilage defect;
Continuous passive motion;
Osteoarthritis;
MMP-3
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study whether the early continuous passive motion (CPM) can prevent the degeneration of articulation after the articular cartilage was experimentally defected, and the effect of the different durations of continuous passive motion therapy. Methods Fifteen New Zealand rabbits were used to establish the model of full-thickness defects of bilateral knee articular cartilage by operation. Then all the animals were divided into groups A, B and C: Group A served as the control group, and groups B and C served as the observation groups and were administered with 2 hours of continuous passive motion a day (group B) and 8 hours of continuous passive motion a day, respectively. All rabbits were sacrificed at the 12th week after operation, and their articular cartilage were observed. The cartilage and synovium were obtained to have the hematoxylin and eosin stain and immunohistochemistry stain. After that, the pathological assessment and calculation of the ratio of MMP-3 positive cells were conducted and compared among groups. Results Group C was lower than groups A and B in terms of the scores with cartilage pathological assessment and the ratio of MMP-3 positive cells(P
