THE CHANGES OF ENDOTHELIN-A RECEPTOR mRNA IN THE CEREBRAL BASILAR ARTERY OF RATS WITH SUBARACHNOID HEMORRHAGE
- VernacularTitle:大鼠蛛网膜下腔出血脑基底动脉内皮素受体mRNA表达的变化
- Author:
Xuequn LIN
- Publication Type:Journal Article
- Keywords:
Subarachnoid hemorrhage;
Cerebral vessel spasm;
Endothelin receptor A;
RT-PCR;
Rat
- From:
Acta Anatomica Sinica
1957;0(04):-
- CountryChina
- Language:Chinese
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Abstract:
Objective To detect the changes of Endothelin-A receptor mRNA in the cerebral basilar artery of rats with experimental subarachnoid hemorrhage-induced cerebral vessel spasm as well as its effect. Methods Fifty-six Wistar rats were randomly divided into normal, experimental,sham-operated and saline-control groups. The experimental group was subdivided into subarachnoid hemorrhage(SAH)2,3,7 and 14?d groups. Reverse transcription polymerse chain reaction was used to study the changes of Endothelin-A receptor mRNA level in the cerebral basilar artery of rats with experimental subarachnoid hemorrhage-induced cerebral vessel. Results ET-A receptor mRNA level of basilar artery in SAH2, 3?d and 7?d group was higher obviously than that of normal group,sham-operated and saline-control groups. That of 14?d group was approximate to normal group.Conclusion ET-A receptor may play an important role in pathogenesis of SAH-induced cerebral vessel spasm.
