MORPHOLOGICAL STUDY ON ASCENDING AORTIC ANEURYSMS INDUCED BY ASCENDING AORTA BANDING
- VernacularTitle:升主动脉缩窄术后大鼠动脉瘤形态学研究
- Author:
Jun FAN
;
Shuling BAI
- Publication Type:Journal Article
- Keywords:
Ascending aorta banding;
Ascending aortic aneurysm;
Matrix metalloproteinases;
Immunohistochemistry;
Rat
- From:
Acta Anatomica Sinica
1957;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the morphology and the cause of the ascending aortic aneurysm induced by ascending aorta banding. Methods Forty young Wistar rats were divided into two groups:the control group (10 rats) and the experiment group (30 rats).The rat models induced by ascending aorta banding were made.The ascending aortas were taken after operation in 3-5 months,and special staining and immuohistochemical staining technique were performed and observed under light microscope. Results The ascending aortic aneurysms were induced by ascending aorta banding of the young Wistar rats 3-5 months after operation.The occurrence of the aneurysm is 63.3%,and the occurrence of dissecting aneurysms is 36.7%.The expression of MMP-2 and MMP-3 is strong in the ascending aortic aneurysm.Conclusion The occurrence of ascending aortic induced by banding ascending aorta of the young Wistar rat is high,and the expression of MMP-2 and MMP-3 is strong.
