The association between rheumatoid arthritis with TLR4 Asp299Gly functional variant:the meta-analysis
- VernacularTitle:类风湿关节炎与TLR4单核苷酸多态性关联研究的Meta分析
- Author:
Zhenglun PAN
;
Yuanchao ZHANG
;
Dongmei XU
- Publication Type:Journal Article
- Keywords:
Arthritis, rheumatoid;
Polymorphism, single nucleotide;
Meta-analysis;
Assosiation
- From:
Chinese Journal of Rheumatology
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association between rheumatoid arthritis (RA) with TLR4 Asp299Gly functional variant. Method The literature about RA and TLR4 Asp299Gly functional variant were searched and the meta-analysis was performed. Results Three studies enrolled 718 RA patients and 1392 controls in total. The analysis showed that the TLR4 Asp299Gly functional variant was neither associated with the susceptibility of RA [OR=1.23 (0.67, 2.25), P=0.5]; nor associated with SE or RF [OR=0.67 and 1.02 respectively]; while the TLR4 Asp299Gly functional variant was associated with the age of onset [OR=-4.35 (-7.45, -1.25), P=0.006]. Conclusion The meta-analysis reveals that the TLR4 Asp299Gly functional variant is not associated with the susceptibility of RA, but the onset of RA is earlier in the AA type than those in the AG type. Further prospective corhort studies should be carreied out in the future, especially in oriential people.
