Study on the preparation and stability of sinomenine liposomes
- VernacularTitle:青藤碱脂质体的制备及稳定性研究
- Author:
Yan WANG
;
Liling ZHOU
- Publication Type:Journal Article
- Keywords:
sinomenine;
liposomes;
preparation;
stability
- From:
Chinese Traditional Patent Medicine
1992;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the preparation and stability of sinomenine liposomes. METHODS Taking entrapment efficiency as index, different preparation methods, including thin film dispersion, reverse-phase evaporation, and aether injection were optimized. The leakage rate, the uptake rate and the storage temperature of the liposomes were studied at the same time. RESULTS The entrapment efficiency of reverse-phase evaporation was the lowest as 48.93 % . The entrapment efficiency of thin film dispersion and aether injection were near, as 68.91 T《B》 % and 66.57 % , respectively. CONCLUSION Thin film dispersion has higher entrapment efficiency and low command to the equipment. So it is suitable for the production of sinomenine liposomes on a large scale.
