Protective effect of Ganduqing Granule on acute hepatic injury
- VernacularTitle:肝毒清颗粒对大鼠急性肝损伤保护作用研究
- Author:
Wanping LI
;
Shunhan XIAO
;
Meijuan CHEN
;
Hua LI
;
Liang LI
;
Zhuo ZHANG
;
Mei WEI
- Publication Type:Journal Article
- Keywords:
Ganduqing Granule (GDQ);
rats;
hepatic injury
- From:
Chinese Traditional Patent Medicine
1992;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To observe the protective effect of Ganduqing Granule(GDQ) on acute hepatic injury. METHODS Sixty male Wistar rats were divided into 6 groups, namely normal control group, model group, Ganduqing large (GDQ Ⅰ), middle(GDQ Ⅱ), small dose(GDQ Ⅲ) groups and Yiganning (YGN) positive group. Acute hepatic injury induced by thioacetamide. The changes of blood serum ALT, AST activity and plasma endotoxin (ET) level and TNF-?, IL-6 levels were measured and livers were taken for pathology examination. RESULTS Plasma ET level and blood serum ALT, AST levels and TNF-?, IL-6 levels were significantly lower than model group ( P
