Expression of extracellular matrix metalloproteinase inducer during normal pregnancy
- VernacularTitle:细胞外基质金属蛋白酶诱导因子在绒毛和胎盘组织中的表达
- Author:
Yongqing WANG
;
Jun LI
;
Tao SHANG
;
Yanling WANG
- Publication Type:Journal Article
- Keywords:
Embryo implantation;
Matrix metalloproteinases;
Chorionic villi
- From:
Chinese Journal of Obstetrics and Gynecology
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of extracellular matrix metalloproteinase inducer (EMMPRIN) during normal pregnancy. Methods The expression of EMMPRIN was studied with immunohistochemistry in normal pregnancy. Results The expression of EMMPRIN was obvious, and appeared mainly on membrane of cytotrophoblast, syncytiotrophoblast, cytotrophoblast column of the villi of gestational weeks 6 to 9, mid-term and term placenta and extravillous cytotrophoblast of deciduas of mid-term and term placenta. The expression reached a peak level at gestational week 6 and gradually decreased from week 7 and stabilized to a low level at mid-term and term placenta when the expression of extravillous cytotrophoblast of deciduas was increased. Conclusion EMMPRIN may be an important factor for implantation during early pregnancy and participate in maintaining gestation during mid-term and term pregnancy.
