Preparation and dissolution of solid dispersion of Fructus Schisandrae Chinensis extracts
- VernacularTitle:五仁醇固体分散体的制备及体外溶出度研究
- Author:
Tie ZHAO
;
Mingfeng QIU
;
Yongyu ZHANG
;
Xiaorong WANG
;
Dawei CHEN
;
Wei JIA
- Publication Type:Journal Article
- Keywords:
alcohol extract of Fructus Schisandrae Chinensis(Wurenchun);
polyvinylpyrrolidone(PVP) K30;
solid dispersion;
solubility;
dissolution
- From:
Chinese Traditional and Herbal Drugs
1994;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare Wurenchun solid dispersion of alcohol extracts of Fructus Schisandrae Chinensis so as to improve the dissolution of its active compound in vitro.Methods The Wurenchun solid dispersions were prepared with various carriers and drug/carrier ratios by mixing the carrier in alcohol extractive solution of FSC directly,and the apparent solubility and dissolution of deoxyschisandrin in them were tested and compared.Results The apparent solubility and dissolution of deoxyschisandrin of Wurenchun solid dispersion(extracts: polyvinylpyrrolidone(PVP) K30=1∶3) were increased remarkably to 5.06 ?g/mL and 43.2% in water individually,including dispersed and dissolved drug whose particle size is below 0.22 ?m,compared with that of the self-prepared Wurenchun capsules.Conclusion Wurenchun solid dispersion made of PVP K30 can remarkably enhance apparent solubility and dissolution of the active compound in vitro.
