Insulin resistance in the intrauterine growth retardation rats
- VernacularTitle:宫内生长迟缓致大鼠胰岛素抵抗的实验研究
- Author:
Yan LIAO
- Publication Type:Journal Article
- Keywords:
Intrauterine growth retardation;
Insulin resistance;
Disease model;
Animal
- From:
Journal of Chongqing Medical University
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the endocrine functions of the islet ? cells and insulin sensitivity in the adult male rats,with intrauterine growth retardation induced by maternal starvation during pregnancy.Methods:The foods were available ad libitum throughout the pregnancy to the control group(n=8) and the rats in the experimental group(n=9) were fed 50% of the control group.The average birth weight of the offspring in the experimental group were below the mean values of the birth weights of the control group more than 2SD,defined as IUGR.The glucose tolerance test and hyperinsulinemic-euglycemic clamp were done in the adult male offspring(n=9 for each group).Results:(1)Litter size was not affected by maternal undernutrition.The birth weights of the rats in the maternal starvation during the pregnancy were significantly lower(4.37?0.34g)than those in the control group(6.42?0.29g) as defined as IUGR.The postnatal survival rate of the IUGR rats(75.4%) is significantly lower than that of the normal offspring(94.9%).The mean weight of the IUGR male rats was still lower than that of control group (279.8?30.3g vs 341.3?36.6g,P
